The Houston Astros beat the Chicago White Sox last night, and my White Sox vs. Astros prediction expects another win for H-Town.
Find out why in my MLB picks for Sept. 3, with first pitch set for 2:10 p.m. ET at Daikin Park in Houston, Texas.
Who will win White Sox vs Astros today: Houston Astros (61%)
Hunter Brown has looked more like Hunter Brown over the past month, pitching to a 3.18 ERA and 3.28 xERA.
That should continue against the Chicago White Sox, who rank 24th in batting average vs. right-handed pitching this season.
Brown has posted a clean 2.78 ERA over seven starts against opponents ranking Bottom 10 in batting average against RHP. He’s set up for success.
Luis Castillo has allowed at least three earned runs in seven of his past eight, and offers the Houston Astros an opportunity to jumpstart their offense.
Back Houston to 63%.
COVERS INTEL: Luis Castillo has allowed a 46.1% hard-hit rate over the past month, second-highest among today's projected starters. White Sox vs Astros Over/Under pick: Over 8.5 (49%)
One area the Astros excel in is drawing walks. They sit 10th in walk rate against right-handed pitching, and that allows them to generate traffic even when the bats aren’t hot.
The Astros have already faced Castillo twice this season and caused him a world of problems. They scored 10 runs over nine innings of work while drawing four walks.
Brown is a very good pitcher but he has struggled with control, sitting in the seventh percentile in walk rate. That will lead to some extra baserunners and help Chicago chip in.
Play to 53%.
White Sox vs Astros home run prediction: Yordan Alvarez (27%)
Castillo allows a lot of power to left-handed hitters. He ranks in the 14th percentile in HR/9 and 12th percentile in SLG, which should have Yordan Alvarez chomping at the bit for this matchup.
Alvarez has hit .359 with a .369 ISO and .728 SLG against right-handed starters who sit in the 30th percentile or worse in those two categories.
His already ridiculous season outputs level up further, making him that much more enticing of a target.
Todd Cordell's 2026 Transparency Record- ML/RL bets: 97-89, -12.36 units
- Over/Under bets: 94-86-6, -4.27 units
White Sox vs Astros market trends
Here is how the smart money from Polymarket traders is coming in on this afternoon's White Sox vs. Astros matchup, with the Astros as the heavy favorite.
White Sox vs Astros weather
This game will be played indoors.
White Sox vs Astros odds
- Moneyline: White Sox 40% | Astros 61%
- Run line: White Sox +1.5 (59%) | Astros -1.5 (42%)
- Over/Under: Over 8.5 (49%) | Under 8.5 (52%)
White Sox vs Astros trend
Chicago owns a 78-61 O/U record this season. Find more MLB betting trends for White Sox vs. Astros.
How to watch White Sox vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Thursday, Sept. 3, 2026 |
| First pitch | 2:10 p.m. ET |
| TV | CHSN, Space City HN |
| White Sox starting pitcher | Luis Castillo (4-10, 5.31 ERA) |
| Astros starting pitcher | Hunter Brown (4-3, 3.33 ERA) |
White Sox vs Astros latest injuries